Onco-Innovations Appoints Dr. John Mackey to Scientific & Clinical Advisory Board

Calgary, Canada – September 5, 2025 – Onco-Innovations Limited (CBOE CA: ONCO) (Frankfurt: W1H, WKN: A3EKSZ) (“Onco“ or the “Company”) is pleased to announce the appointment of Dr. John Mackey, Professor Emeritus in the Department of Oncology at the University of Alberta, to its Scientific and Clinical Advisory Board. His expertise will support Onco’s efforts in aligning translational research with clinical execution, particularly as the Company progresses toward later-stage development of its PNKP inhibitor program.

Dr. Mackey has extensive experience in oncology, clinical trials, and cancer drug development. He previously served as Director of the Clinical Trial Unit at the Cross Cancer Institute and as Executive Director of Translational Research in Oncology (TRIO), a not-for-profit academic clinical research organization responsible for interventional cancer trials involving more than 22,000 participants[1] globally.

He is a co-founder of Pacylex Pharmaceuticals, a biotechnology company developing therapies targeting N-myristoyl transferases, currently in Phase II international trials. He is also the CEO of illumiSonics, which is developing Microcellular Laser Imaging (MLI) technology for molecular histology. Additional initiatives include founding SMHeartCard, a personal emergency medication carriage system, and co-developing CWTA, a statistical method for analyzing multiple health states in clinical trials. Across these ventures, Dr. Mackey has been directly involved in advancing novel therapies from early-stage development through to clinical evaluation and commercialization, providing relevant experience for Onco’s translational and commercial ambitions.

Dr. Mackey holds 12 patents and has co-authored over 300 peer-reviewed publications covering a range of topics, including membrane transporter biochemistry, oncology clinical trials, cancer diagnostics, physical activity as an intervention for cancer patients, and statistical methodologies. He is a Fellow of the Canadian Academy of Health Sciences.

In his role on the Scientific & Clinical Advisory Board, Dr. Mackey will contribute his expertise in clinical development, trial methodology, and translational oncology. His responsibilities will include advising on clinical strategy related to the Company’s PNKP Inhibitor Technology (NP/A83) and other ongoing research programs.

“Dr. Mackey’s work has consistently bridged discovery research with clinical implementation, particularly in areas where novel mechanisms require thoughtful trial design and regulatory navigation. His direct experience with first-in-class oncology therapeutics and leadership across academic and biotech environments aligns closely with the development path for our PNKP inhibitor program,” stated Thomas O’Shaughnessy, CEO of Onco-Innovations.

About Onco-Innovations Limited

Onco-Innovations is a Canadian-based company dedicated to cancer research and treatment, specializing in oncology. Onco’s mission is to pursue the prevention and treatment of cancer through pioneering research and innovative solutions. The company has secured an exclusive worldwide license to patented technology that targets solid tumours.

ON BEHALF OF ONCO-INNOVATIONS LIMITED,

“Thomas O’Shaughnessy”

Chief Executive Officer

For more information, please contact:

Thomas O’Shaughnessy

Chief Executive Officer

Tel: + 1 888 261 8055

investors@oncoinnovations.com

Forward-Looking Statements Caution. This news release contains forward-looking statements relating to the further development, potential commercialization and benefits of the Company’s technologies and the prospects of the Company, and the Company’s business and plans generally, and other statements that are not historical facts. Forward-looking statements are often identified by terms such as “will”, “may”, “potential”, “should”, “anticipate”, “expects” and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include the failure to further develop, prove out or commercialize its technologies, and other risks detailed from time to time in the filings made by the Company with securities regulators. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable law.

[1] https://trioncology.org/